Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method

Author(s): M. Ablise, A. Cartier, G. Siest, S. Visvikis, V. Loppinet

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 2 , 2002


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Abstract:

Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.

Keywords: acat inhibitors, molecular modeling, glycyrrhizin, glycyrrhiza glabra

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2002
Page: [97 - 102]
Pages: 6
DOI: 10.2174/1389557024605528
Price: $65

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