Abstract
αVβ3 integrin, a cell surface protein, has been targeted by a variety of natural and synthetic antagonists in the search for potential cancer and osteoporosis drug candidates. This review discusses chemical and structural requirements for activity and selectivity deduced from SAR studies and draws a tentative picture of the pharmacophore.
Keywords: vitronectin receptor, activity and selectivity, cell surface protein, antagonists, heterodimeric non-covalent proteins, tumour metastasis, thrombotic disorder treatment, snake venom proteins, pseudo-peptides, pseudo-peptidic antagonists
Mini-Reviews in Medicinal Chemistry
Title: Vitronectin Receptor -αVβ3 Integrin- Antagonists: Chemical and Structural Requirements for Activity and Selectivity
Volume: 2 Issue: 6
Author(s): Christophe Henry, Nicolas Moitessier and Yves Chapleur
Affiliation:
Keywords: vitronectin receptor, activity and selectivity, cell surface protein, antagonists, heterodimeric non-covalent proteins, tumour metastasis, thrombotic disorder treatment, snake venom proteins, pseudo-peptides, pseudo-peptidic antagonists
Abstract: αVβ3 integrin, a cell surface protein, has been targeted by a variety of natural and synthetic antagonists in the search for potential cancer and osteoporosis drug candidates. This review discusses chemical and structural requirements for activity and selectivity deduced from SAR studies and draws a tentative picture of the pharmacophore.
Export Options
About this article
Cite this article as:
Henry Christophe, Moitessier Nicolas and Chapleur Yves, Vitronectin Receptor -αVβ3 Integrin- Antagonists: Chemical and Structural Requirements for Activity and Selectivity, Mini-Reviews in Medicinal Chemistry 2002; 2 (6) . https://dx.doi.org/10.2174/1389557023405602
DOI https://dx.doi.org/10.2174/1389557023405602 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Assessment of the Health Effects of Chemicals in Humans: I. QSAR Estimation of the Maximum Recommended Therapeutic Dose (MRTD) and No Effect Level (NOEL) of Organic Chemicals Based on Clinical Trial Data1
Current Drug Discovery Technologies Integrins Modulate Cellular Fibrogenesis at Multiple Levels: Regulation of TGF-β Signaling
Endocrine, Metabolic & Immune Disorders - Drug Targets Anti-Endotoxin Agents. 3. Rapid Identification of High-Affinity Lipopolysaccharide-Binding Compounds in a Substituted Polyamine Library
Combinatorial Chemistry & High Throughput Screening Self-assembly of DNA-based Nanomaterials and Potential Application in Drug Delivery
Current Topics in Medicinal Chemistry Practical Aspects of NMR-based Fragment Discovery
Current Topics in Medicinal Chemistry Immunological Targets in Inflammation from the Small Molecule Perspective
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Bio Fabrication of Silver Nanoparticle from Argemone mexicana for the Control of Aedes albopictus and their Antimicrobial Activity
Current Pharmaceutical Biotechnology Synthesis and Antimicrobial Evaluation of New Pyrazoline and Pyrazolinyl Thiazole Derivatives Bearing Tetrazolo[1,5-a]quinoline Moiety
Letters in Drug Design & Discovery Systematic Review on Treatment Trials of Tocilizumab: A Repurposing Drug against COVID-19
Reviews on Recent Clinical Trials Design of Cathepsin K Inhibitors for Osteoporosis
Current Topics in Medicinal Chemistry High Throughput Screen Identifies Natural Product Inhibitor of Phenylalanyl-tRNA Synthetase from Pseudomonas aeruginosa and Streptococcus pneumoniae
Current Drug Discovery Technologies Binding Modes of 2-Phenylamino-6-oxopurines to Herpes Simplex Virus Thymidine Kinases
Letters in Drug Design & Discovery Coumarins and Quinolones as Effective Multiple Targeted Agents Versus Covid-19: An <i>In Silico</i> Study
Medicinal Chemistry ADAM Metalloproteinases as Potential Drug Targets
Current Medicinal Chemistry Computational Studies on Transthyretin
Current Medicinal Chemistry An Updated Review on COVID-19
Infectious Disorders - Drug Targets Therapeutic Applications of Fucoidans and their Potential to Act Against COVID-19
Current Pharmaceutical Design Microtubule-targeting Anticancer Agents from Marine Natural Substance
Anti-Cancer Agents in Medicinal Chemistry QSAR Modeling for the Antimalarial Activity of 1,4-Naphthoquinonyl Derivatives as Potential Antimalarial Agents
Current Computer-Aided Drug Design Application of SMILES Notation Based Optimal Descriptors in Drug Discovery and Design
Current Topics in Medicinal Chemistry