Title: Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimers Disease
VOLUME: 2 ISSUE: 1
Author(s):Felix Hernandez, Filip Lim, Jose J. Lucas, Concepcion Perez-Martin, Franscisco Moreno and Jesus Avila
Affiliation:Centro de Biologia Molecular Severo Ochoa CSIC / UAM, Fac. Ciencias. Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid. Spain
Keywords:Tau Pathology, Alzheimers Disease, tau hyperphosphorylation
Abstract: The deposit of two proteins in the brain characterizes Alzheimers disease: deposits of β-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimers disease.
