Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimers Disease

Author(s): Felix Hernandez, Filip Lim, Jose J. Lucas, Concepcion Perez-Martin, Franscisco Moreno, Jesus Avila

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 1 , 2002

Become EABM
Become Reviewer
Call for Editor


The deposit of two proteins in the brain characterizes Alzheimers disease: deposits of β-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimers disease.

Keywords: Tau Pathology, Alzheimers Disease, tau hyperphosphorylation

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2002
Page: [51 - 58]
Pages: 8
DOI: 10.2174/1389557023406557

Article Metrics

PDF: 15