Analysis of Fibril Formation of Amyloid-β- Protein by Stretched Exponential Function

Author(s): Ken-ichi Shinozaki, Takeo Konakahara, Hiroaki Okuno, Masato Kodaka

Journal Name: Protein & Peptide Letters

Volume 10 , Issue 6 , 2003

Become EABM
Become Reviewer
Call for Editor


Kinetic behavior of aggregation of amyloid-β-protein (Aβ) is represented by a stretched exponential function, F=A{1-exp(-Btn)}. Differences in temperature-dependence of A, B and n are studied for Aβ 1-40 and Aβ 1-42. As the temperature is lowered, parameter A is increased, parameter B is decreased and parameter n is increased in Aβ 1-40, while these parameters are less sensitive to temperature in a more hydrophobic protein Aβ 1-42. ln B is a linear function of n, which is shown by ln B = -6.34n + 3.69.

Keywords: fibril formation, amyloid-b-protein, stretched exponential function, hydrophobic protein

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2003
Page: [569 - 574]
Pages: 6
DOI: 10.2174/0929866033478582
Price: $65

Article Metrics

PDF: 2