Title: Electronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors
VOLUME: 3 ISSUE: 4
Author(s):A. Dimoglo, E. Sim, N. Shvets and V. Ahsen
Affiliation:Gebze Institute of Technology, PK 141, Gebze / Kocaeli, 41400, Turkey
Keywords:cox-2, nsaids, structure-activity relationships (sar)
Abstract: A large series of cyclooxygenase-2 (COX-2) inhibitors with diverse skeletons were investigated by means of the Electronic-Topological Method. A system for the COX-2 inhibitor activity prognostication was built with 6 pharmacophores and 6 anti-pharmacophores. The forecasting ability of the system was also tested on different structures, which differ from those that characterize the series studied.
