Electronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors

Author(s): A. Dimoglo, E. Sim, N. Shvets, V. Ahsen

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 4 , 2003

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A large series of cyclooxygenase-2 (COX-2) inhibitors with diverse skeletons were investigated by means of the Electronic-Topological Method. A system for the COX-2 inhibitor activity prognostication was built with 6 pharmacophores and 6 anti-pharmacophores. The forecasting ability of the system was also tested on different structures, which differ from those that characterize the series studied.

Keywords: cox-2, nsaids, structure-activity relationships (sar)

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Article Details

Year: 2003
Page: [281 - 294]
Pages: 14
DOI: 10.2174/1389557033488060
Price: $65

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