Inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B)

Author(s): Scott D. Taylor

Journal Name: Current Topics in Medicinal Chemistry

Volume 3 , Issue 7 , 2003

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Recent studies have demonstrated that protein tyrosine phosphatase 1B (PTP1B) is involved in the down regulation of insulin signaling. Selective inhibitors of PTP1B hold much promise for the treatment of type 2 diabetes mellitus and obesity. Consequently much effort, by both industry and academia, has been devoted towards the development of PTP1B specific inhibitors. This article gives an overview of reports that have appeared in the primary scientific literature on the development of PTP1B inhibitors, starting from the days of early development up to September of 2002.

Keywords: Protein Tyrosine Phosphatase

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Article Details

Year: 2003
Page: [759 - 782]
Pages: 24
DOI: 10.2174/1568026033452311
Price: $65

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