Diabetes, the Renin-Angiotensin System and Heart Disease

Author(s): Hoong Sern Lim, Gregory Y.H. Lip

Journal Name: Current Vascular Pharmacology

Volume 1 , Issue 2 , 2003

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Despite recent advances, cardiovascular disease continues to be the leading cause of death among patients with diabetes. Diabetes-related heart disease makes up the majority of the cardiovascular morbidity and mortality and this clinical entity results from synergistic interaction amongst various overlapping mechanisms. Diabetes-related heart disease is characterised by a propensity to develop premature, diffuse atherosclerotic disease, structural and functional abnormalities of the microvasculature, autonomic dysfunction and intrinsic myocardial dysfunction (the so-called diabetic ‘cardiomyopathy’), all of which are exacerbated by hypertension and diabetic nephropathy. The renin-angiotensinaldosterone system possesses various autocrine and paracrine effects which drive most of the pathophysiological mechanisms in diabetes-related heart disease. This review aims to describe the expanding role of the renin-angiotensinaldosterone system, the complex entity of diabetes-related heart disease and the (emerging) evidence for specific inhibition of the renin-angiotensin-aldosterone system in diabetes.

Keywords: renin-angiotensin system, diabetes, cardiovascular disease

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Article Details

Year: 2003
Page: [225 - 238]
Pages: 14
DOI: 10.2174/1570161033476682
Price: $65

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