Molecular Diversity of Hydroxamic Acids: Part II. Potential Therapeutic Applications

Author(s): Boliang Lou, Kexin Yang

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 6 , 2003

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Abstract:

A hydroxamic acid moiety has been demonstrated as the key structural element in many highly potent and selective inhibitors against a variety of metalloprotease enzymes, such as MMPs, TACE, HDAC, PDF, etc. Over the last several years, there has been a rapid growth of literature and patent applications dealing with the development of the hydroxamic acid-based inhibitors. This review highlights the most recent examples to show their potential therapeutic applications.

Keywords: hydroxamic acids, mmps, tace, hdac, hydroxamic acid-based inhibitors

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Article Details

VOLUME: 3
ISSUE: 6
Year: 2003
Page: [609 - 620]
Pages: 12
DOI: 10.2174/1389557033487872
Price: $65

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