DNA Topoisomerases as Targets for Antiprotozoal Therapy

Author(s): R. P. Bakshi, T. A. Shapiro

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 6 , 2003


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Abstract:

Diseases caused by parasitic protozoa present a health problem of immense magnitude, and there is an urgent need for safe and effective new therapies. DNA topoisomerases are clinically relevant targets for anticancer and anti-bacterial agents. Inhibitor studies on parasite topoisomerases have revealed that these enzymes have great promise as molecular targets for anti-parasitics, and have helped to dissect the basic biology of DNA topoisomerases in these organisms. This review provides a brief introduction to DNA topoisomerases and anti-topoisomerase drugs, and an overview of studies on protozoal DNA topoisomerases and their inhibitors.

Keywords: dna topoisomerase, antiparasitic, poison, inhibitor, trypanosoma, plasmodium, leishmania, protozoa

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Article Details

VOLUME: 3
ISSUE: 6
Year: 2003
Page: [597 - 608]
Pages: 12
DOI: 10.2174/1389557033487863
Price: $65

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