Plant-Derived Triterpenoids as Potential Antineoplastic Agents

Author(s): W. N. Setzer, M. C. Setzer

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 6 , 2003


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Abstract:

Man has relied on plants as a source of medicinal agents for centuries. Today, with the specter of antibiotic resistance, emerging infectious diseases, and cancers, phytochemicals continue to provide new structural leads for the chemotherapeutic industry. A number of triterpenoids have shown promise as antineoplastic agents. Members of the cycloartane, lupane, ursane, oleanane, friedelane (especially quinone methides), dammarane, cucurbitacin, and limonoid triterpenoids, have demonstrated anti-proliferative activity on various cancer cell lines. This review covers the recent developments regarding antineoplastic / cytotoxic triterpenoids, excluding saponins, from higher plants.

Keywords: triterpenoids, cytotoxic, antineoplastic, cancer

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Article Details

VOLUME: 3
ISSUE: 6
Year: 2003
Page: [540 - 556]
Pages: 17
DOI: 10.2174/1389557033487854
Price: $65

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