Abstract
For over thirty years it has been evident that there is altered glycosyltransferase activity in neoplastic tissue when compared to healthy tissue. It has also long been speculated that disruption of the neoplastic expression of sialic acid on cellular glycoconjugates, is a valid target in anti-metastatic therapeutic development. Over the years attempts have been made to synthesize inhibitors of sialyltransferases in a effort to assist in the validation or dissolution of these enzymes as potential therapeutic targets.
Keywords: sialyltransferase, inhibitors, metastasis, glycoconjugates
Mini-Reviews in Medicinal Chemistry
Title: Inhibitors of Sialyltransferases: Potential Roles in Tumor Growth and Metastasis
Volume: 3 Issue: 6
Author(s): N. B. Drinnan, J. Halliday and T. Ramsdale
Affiliation:
Keywords: sialyltransferase, inhibitors, metastasis, glycoconjugates
Abstract: For over thirty years it has been evident that there is altered glycosyltransferase activity in neoplastic tissue when compared to healthy tissue. It has also long been speculated that disruption of the neoplastic expression of sialic acid on cellular glycoconjugates, is a valid target in anti-metastatic therapeutic development. Over the years attempts have been made to synthesize inhibitors of sialyltransferases in a effort to assist in the validation or dissolution of these enzymes as potential therapeutic targets.
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Cite this article as:
Drinnan B. N., Halliday J. and Ramsdale T., Inhibitors of Sialyltransferases: Potential Roles in Tumor Growth and Metastasis, Mini-Reviews in Medicinal Chemistry 2003; 3 (6) . https://dx.doi.org/10.2174/1389557033487881
DOI https://dx.doi.org/10.2174/1389557033487881 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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