Anticonvulsant Activity Of Benzylamides Of Some Amino Acids And Heterocyclic Acids

Author(s): Ryszard Paruszewski, Marzanna Strupinska, Grazyna Rostafinska-Suchar, James P. Stables

Journal Name: Protein & Peptide Letters

Volume 10 , Issue 5 , 2003


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Abstract:

A series of new potential anticonvulsants have been synthesized. They are N-methyl benzylamides of N-methyl Asp and N-methyl Glu (R and S), benzylamides of some heterocyclic acids and their Noxides and benzylamides of two heteroalicyclic acids. The obtained compounds were evaluated in the Anticonvulsant Screening Project (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH.

Keywords: anticonvulsants, n-methyle-glu, n-methyl-asp derivatives, heterocyclic acid derivaties

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2003
Page: [475 - 482]
Pages: 8
DOI: 10.2174/0929866033478636
Price: $65

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