Synthesis of Bisquaternary Symmetric - X,δ-Bis(2-Hydroxyiminomethylpyridinium) Alkane Dibromides and Their Reactivation of Cyclosarin-Inhibited Acetylcholinesterase

Title: Synthesis of Bisquaternary Symmetric - X,δ-Bis(2-Hydroxyiminomethylpyridinium) Alkane Dibromides and Their Reactivation of Cyclosarin-Inhibited Acetylcholinesterase

Volume: 1 Issue: 1

Author(s): Kamil Kuca, Jiri Cabal, Jiri Patocka and Jiri Kassa

Affiliation:

Keywords: oximes, reactivation, acetylcholinesterase, cyclosarin

Abstract: Preparations of the symmetric bisquaternary oximes - 1,4-bis(2-hydroxyiminomethypyridinium) butane dibromide and 1,3-bis(2-hydroxyiminomethypyridinium)propane dibromide, and their abilities to reactivate cyclosarin-inhibited acetylcholinesterase are described. Common reactivator (pralidoxime) was used as a standard for comparison of the reactivation efficacy. The first oxime seems to be very good reactivator of cyclosarin-inhibited acetylcholinesterase.

Cite this article as:

Kuca Kamil, Cabal Jiri, Patocka Jiri and Kassa Jiri, Synthesis of Bisquaternary Symmetric - X,δ-Bis(2-Hydroxyiminomethylpyridinium) Alkane Dibromides and Their Reactivation of Cyclosarin-Inhibited Acetylcholinesterase, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488761