Synthesis of New Ligands Derived from Polyphosphonates Partial Esters

Author(s): Pascale Even, Erwann Guenin, Mounya Benramdame, Patricia Quidu, Driss El Manouni, Marc Lecouvey

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 1 , 2004

Become EABM
Become Reviewer
Call for Editor


In the search for new chelation therapy drugs for the treatment of metal intoxications, some new polyphosphonated chelating ligands have been synthesized. They were obtained by means of an Arbuzov reaction followed by addition of the corresponding dialkylphosphite. The regioselective dealkylation was then carried out by using trimethylsilyl halide.

Keywords: tetraphosphonate, chelating agents, restrained geometry, partial deprotection

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2004
Page: [75 - 77]
Pages: 3
DOI: 10.2174/1570178043488563

Article Metrics

PDF: 15