The Impact of Combinatorial Methodologies on Medicinal Chemistry

Author(s): Rosario M. Sanchez-Martin, Stifun Mittoo, Mark Bradley

Journal Name: Current Topics in Medicinal Chemistry

Volume 4 , Issue 7 , 2004

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Combinatorial chemistry has had a major impact on the discovery and optimisation of potential lead compounds. This review details some of the fundamental principles behind combinatorial chemistry and describes a variety of methods employed in the search for new therapeutically interesting compounds including the concept of dynamic combinatorial chemistry as a method of selecting active compounds from a mixture. It also outlines methods used to analyse resin bound products and describes how solution phase library generation may be aided by the use of resin bound reagents and scavengers.

Keywords: Methodologies, scavengers, combinatorial chemistry

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Article Details

Year: 2004
Page: [653 - 669]
Pages: 17
DOI: 10.2174/1568026043451113
Price: $65

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