Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors

Author(s): E. M.F. Muri, H. Mishra, S. M. Stein, J. S. Williamson

Journal Name: Letters in Drug Design & Discovery

Volume 1 , Issue 1 , 2004

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A computer-generated homology model of the antimicrobial target Helicobacter pylori urease was derived, using the x-ray crystal structure of Klebsiella aerogenes as a template, in order to design novel urease inhibitors. Based on these computational studies, several heterocyclic hydroxamic acid derivatives have been designed, synthesized, and examined for their ability to inhibit urease activity.

Keywords: helicobacter pylori, antimicrobial, urease, hydroxamic acids

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Article Details

Year: 2004
Page: [30 - 34]
Pages: 5
DOI: 10.2174/1570180043485680

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