Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors

Title: Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors

VOLUME: 1 ISSUE: 1

Author(s):E. M.F. Muri, H. Mishra, S. M. Stein and J. S. Williamson

Affiliation:Department of Medicinal Chemistry, University of Mississippi, University MS 38677, USA.

Keywords:helicobacter pylori, antimicrobial, urease, hydroxamic acids

Abstract: A computer-generated homology model of the antimicrobial target Helicobacter pylori urease was derived, using the x-ray crystal structure of Klebsiella aerogenes as a template, in order to design novel urease inhibitors. Based on these computational studies, several heterocyclic hydroxamic acid derivatives have been designed, synthesized, and examined for their ability to inhibit urease activity.

Cite this article as:

E. M.F. Muri, H. Mishra, S. M. Stein and J. S. Williamson, “ Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors”, Letters in Drug Design & Discovery (2004) 1: 30. https://doi.org/10.2174/1570180043485680

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