Versatile Synthesis of Boc Protected Hydrazinoacetic Acid and its Application to the Chemoselective Ligation of Tasp Molecules

Author(s): Damiano Banfi, Manfred Mutter, Luc Patiny.

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 6 , 2004

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This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Bochydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis.

Keywords: chemoselective ligation, template assembled synthetic proteins (tasp), n-boc-3-(4-cyanophenyl)oxaziridine (bpco), synthesis, amino acids, electrophilic amino group

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Article Details

Year: 2004
Page: [539 - 542]
Pages: 4
DOI: 10.2174/0929866043406274
Price: $65

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