The Relationship Between the Py3 Amino Acid in the Phosphopeptide Ligands and the Specificity for Various Sh2 Domains

Author(s): Keun-Hyeung Lee, See-Hyoung Park.

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 6 , 2004

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After consideration of the tertiary structure of the pY+3 binding pocket in SH2 domains, isoleucine of Ac-pYEEIE was replaced with various unnatural aliphatic amino acids and the binding affinities for Lck, Src, and Fyn SH2 domains were measured. We determined the characteristics of the amino acid at the pY+3 position in the phosphopeptide ligands for the specificity for the SH2 domains.

Keywords: sh2 domain, specificity, phosphopeptide, ligand, lck, src, fyn

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Article Details

Year: 2004
Page: [527 - 532]
Pages: 6
DOI: 10.2174/0929866043406337
Price: $65

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