Synthesis and Reactivity of α-Halogenated, C-Protected β-Enamino Acids

Author(s): S. Fustero, E. Salavert, J. F. Sanz-Cervera, R. Roman, B. Fernandez-Gutierrez.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 2 , 2004

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C-Protected β-enamino acids (I) reacted with one equivalent of Nhalosuccinimides (NXS) to furnish their α-halogenated derivatives (II). These compounds were then successfully transformed into halogenated uracil derivatives (III) through reaction with triphosgene, followed by 5-membered ring-opening under acidic conditions.

Keywords: halogenation, enamino acid, uracil, oxazoline

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Article Details

Year: 2004
Page: [163 - 167]
Pages: 5
DOI: 10.2174/1570178043488545
Price: $65

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