Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists

Author(s): Marlon Cowart, Robert Altenbach, Lawrence Black, Ramin Faghih, Chen Zhao, Arthur A. Hancock

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 9 , 2004

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Abstract:

The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.

Keywords: non-nimidazole, histamine, h3, review, antagonist, inverse agonist

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Article Details

VOLUME: 4
ISSUE: 9
Year: 2004
Page: [979 - 992]
Pages: 14
DOI: 10.2174/1389557043403215
Price: $65

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