Abstract
The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.
Keywords: non-nimidazole, histamine, h3, review, antagonist, inverse agonist
Mini-Reviews in Medicinal Chemistry
Title: Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists
Volume: 4 Issue: 9
Author(s): Marlon Cowart, Robert Altenbach, Lawrence Black, Ramin Faghih, Chen Zhao and Arthur A. Hancock
Affiliation:
Keywords: non-nimidazole, histamine, h3, review, antagonist, inverse agonist
Abstract: The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.
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Cite this article as:
Cowart Marlon, Altenbach Robert, Black Lawrence, Faghih Ramin, Zhao Chen and Hancock A. Arthur, Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists, Mini-Reviews in Medicinal Chemistry 2004; 4 (9) . https://dx.doi.org/10.2174/1389557043403215
DOI https://dx.doi.org/10.2174/1389557043403215 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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