Histamine H3 Receptor Agonists

Author(s): I. J.P. De Esch, K. J. Belzar

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 9 , 2004

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The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimesconflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.

Keywords: histamine, h3, gpcr, agonist, isoform, activity, efficacy, affinity

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Article Details

Year: 2004
Page: [955 - 963]
Pages: 9
DOI: 10.2174/1389557043403134
Price: $65

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