To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.
Keywords: Vanadyl compound, insulinomimetic activity, diabetes mellitus, blood circulation monitoring-electron, paramagnetic resonance (BCM-EPR), pharmacokinetic analysis, bioavailability, enteric-coated capsule
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