The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarbazones and Their Metal Complexes

Author(s): H. Beraldo, D. Gambinob

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 1 , 2004

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The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.

Keywords: Semicarbazones, thiosemicarbazones, biological activity, pharmacological applications, bioactive metal complexes, mechanisms of action

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Article Details

Year: 2004
Page: [31 - 39]
Pages: 9
DOI: 10.2174/1389557043487484

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PDF: 161