The Application of X-ray, NMR, and Molecular Modeling in the Design of MMP Inhibitors

Author(s): Thomas S. Rush III, Robert Powers

Journal Name: Current Topics in Medicinal Chemistry

Volume 4 , Issue 12 , 2004

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The following review discusses the successful application of X-ray, NMR, and molecular modeling in the design of potent and selective inhibitors of matrix metalloproteinases (MMPs) and TNFα-converting enzyme (TACE) from Wyeth. The importance of protein and ligand mobility as it impacts structure-based design is also discussed. The MMPs are an active target for a variety of diseases, including cancer and arthritis.

Keywords: structure-based drug design, matrix metalloproteinase, matrix metalloprotease, x-ray, nmr, molecular modeling, inhibitor, mmp

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Article Details

Year: 2004
Page: [1311 - 1327]
Pages: 17
DOI: 10.2174/1568026043387999
Price: $65

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