Pharmacogenomic Considerations of the Insertion / Deletion Gene Polymorphism of the Angiotensin I-Converting Enzyme and Coronary Artery Disease

Author(s): Danije Petrovic, Borut Peterlin

Journal Name: Current Vascular Pharmacology

Volume 2 , Issue 3 , 2004

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Gene polymorphisms of components of the renin-angiotensin system, angiotensinogen, angiotensin I-converting enzyme (ACE) and angiotensin II type 1 receptor (AT-1), have been considered to contribute to inherited predisposition towards coronary artery disease (CAD). The best analyzed is the insertion / deletion (I / D) gene polymorphism of the ACE gene. Several studies suggest that the ACE D allele is associated with the occurrence of CAD and myocardial infarction. Moreover, the I / D polymorphism of the ACE gene has been thought to be related to diverse responses to drugs. Modern gene technologies may therefore provide the information, which may help to identify disease-associated genes and determine the responsiveness to a given drug.

Keywords: renin-angiotensin system, pharmacogenomics, single nucleotide polymorphism, coronary artery disease, therapy

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Article Details

Year: 2004
Page: [271 - 279]
Pages: 9
DOI: 10.2174/1570161043385637
Price: $65

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