Induction of Cellular Oxidative Stress by the β-amyloid Peptide Involved in Alzheimers disease

Author(s): Gillian L. Gibson, David Allsop, Brian M. Austen

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 3 , 2004

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β-amyloid, the 39-43 amino acid peptide fragment originating from amyloid precursor protein, is today, generally accepted as the biological entity responsible for causing the debilitating human disorder Alzheimers disease. Understanding the exact biological effects of β-amyloid in vitro and in vivo is clearly important to provide therapeutic strategies for the disease. Recent in vitro studies have focused on the production of reactive oxygen species by aggregating β- amyloid, but the cellular effects of β-amyloid induced reactive oxygen species production have not been fully elucidated.

Keywords: alzheimers disease, reactive oxygen species, hydrogen peroxide, superoxide, nitric oxide

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Article Details

Year: 2004
Published on: 01 March, 2012
Page: [257 - 270]
Pages: 14
DOI: 10.2174/0929866043407101
Price: $65

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