Neuroprotection by the α2-Adrenoceptor Agonist, Dexmedetomidine, in Experimental Stroke Models

Author(s): Kirsi Puurunen, Jukka Jolkkonen, Juhani Sivenius

Journal Name: Vascular Disease Prevention (Discontinued)

Volume 1 , Issue 2 , 2004


Dexmedetomidine is a selective α2-adrenoceptor agonist, which has been shown to be neuroprotective in experimental cerebral ischemia models. Dexmedetomidine administration induces sedation and it has been used as a veterinary sedative in a racemic mixture called medetomidine and recently also clinically in the intensive care unit. Dexmedetomidine treatment has been found to be neuroprotective in cerebral ischemia and some excitotoxic models. The neuroprotective effect of dexmedetomidine could be utilised in prevention of ischemic damage and memory disturbances following by major surgery causing cerebrovascular events.

Keywords: alpha-adrenergic, brain, dexmedetomidine, ischemia, neuroprotection

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2004
Page: [117 - 122]
Pages: 6
DOI: 10.2174/1567270010401020117
Price: $58