Vatairea Macrocarpa Lectin Induces Paw Edema With Leukocyte Infiltration.

Author(s): Nylane M.N. Alencar, Ana M.S. Assreuy, David N. Criddle, Emmanuel P. Souza, Pedro M.G. Soares, Alexandre Havt, Karoline S. Aragao, Daniel P. Bezerra, Ronaldo A. Ribeiro, Benildo S. Cavada

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 2 , 2004

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A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400μg / paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.

Keywords: paw edema,, leukocyte infiltration,, Vatairea macrocarpa lectin.

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Article Details

Year: 2004
Page: [195 - 200]
Pages: 6
DOI: 10.2174/0929866043478284
Price: $65

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