DNA, PNA, and Their Derivatives for Precise Genotyping of SNPs

Author(s): A. Kuzuya, J.- M. Zhou, M. Komiyama

Journal Name: Mini-Reviews in Organic Chemistry

Volume 1 , Issue 1 , 2004

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Abstract:

Two new approaches for SNP genotyping are described. The one is based on tandem site-selective RNA scission and the genotype is determined by MALDI-TOF / MS analyses of clipped short RNA. The other is visual SNP genotyping with combinations of peptide nucleic acid (PNA) and single-stranded DNA specific nucleases.

Keywords: snp genotyping, rna, pna, selective scission, acridine, nuclease

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2004
Page: [125 - 131]
Pages: 7
DOI: 10.2174/1570193043488999

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