Direct and Indirect Enzymatic Methods for the Preparation of Enantiopure Cyclic β-Amino Acids and Derivatives from β-Lactams

Title: Direct and Indirect Enzymatic Methods for the Preparation of Enantiopure Cyclic β-Amino Acids and Derivatives from β-Lactams

Volume: 1 Issue: 1

Author(s): E. Forro and F. Fulop

Affiliation:

Keywords: lactam, amino acid, cispentacin, ring opening, enzymatic catalysis

Abstract: Direct enzymatic methods for the preparation of enantiopure cyclic β-amino acids (e.g. cispentacin) and β-lactams through the enzyme-catalyzed enantioselective ring opening of β-lactams in water and organic solvents are reviewed. Indirect methods through the lipase-catalyzed asymmetric acylation of N-hydroxymethylated β-lactams or the lipase-catalyzed hydrolysis of the corresponding ester derivatives, followed by ring opening, are also surveyed.

Cite this article as:

Forro E. and Fulop F., Direct and Indirect Enzymatic Methods for the Preparation of Enantiopure Cyclic β-Amino Acids and Derivatives from β-Lactams, Mini-Reviews in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570193043488908