Direct and Indirect Enzymatic Methods for the Preparation of Enantiopure Cyclic β-Amino Acids and Derivatives from β-Lactams

Author(s): E. Forro, F. Fulop

Journal Name: Mini-Reviews in Organic Chemistry

Volume 1 , Issue 1 , 2004

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Direct enzymatic methods for the preparation of enantiopure cyclic β-amino acids (e.g. cispentacin) and β-lactams through the enzyme-catalyzed enantioselective ring opening of β-lactams in water and organic solvents are reviewed. Indirect methods through the lipase-catalyzed asymmetric acylation of N-hydroxymethylated β-lactams or the lipase-catalyzed hydrolysis of the corresponding ester derivatives, followed by ring opening, are also surveyed.

Keywords: lactam, amino acid, cispentacin, ring opening, enzymatic catalysis

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Article Details

Year: 2004
Page: [93 - 102]
Pages: 10
DOI: 10.2174/1570193043488908

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