Cyclosporin A: A Therapeutic Strategy in Allergic Diseases

Author(s): Nettis Eustachio, Colanardi Maria Cristina, Ferrannini Antonio

Journal Name: Letters in Drug Design & Discovery

Volume 1 , Issue 4 , 2004

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Abstract:

Cyclosporin A (CsA) is a fungal metabolite that has immunomodulatory and anti-inflammatory effects. Cyclosporin binds to cyclophilin, inhibiting CD4-T-cell activation. In this paper we discuss the mechanism of action of CsA and its role as a novel approach for the treatment of allergic disease.

Keywords: allergic contact dermatitis, asthma, atopic dermatitis, cyclosporin, ocular allergic diseases, urticaria

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Article Details

VOLUME: 1
ISSUE: 4
Year: 2004
Page: [300 - 307]
Pages: 8
DOI: 10.2174/1570180043398650
Price: $65

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