Secretase-Mediated Cell Surface Shedding of the Angiotensin-Converting Enzyme

Author(s): Edward T. Parkin, Anthony J. Turner, Nigel M. Hooper

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 5 , 2004

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Angiotensin-converting enzyme (ACE) is an example of a membrane-bound protein, which is shed from the cell surface in a soluble form by a post-translational proteolytic cleavage event involving a secretase. The secretase cleavage site in somatic ACE has been mapped to Arg-1203 / Ser-1204, 24 residues proximal to the membrane-anchoring domain and the ADAM (‘a d isintegrin a nd m etalloprotease’) family of proteins may be involved in ACE shedding.

Keywords: ace, angiotensin, disintegrin, hypertension, metalloproteinase, proteolysis, secretase, shedding

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Article Details

Year: 2004
Page: [423 - 432]
Pages: 10
DOI: 10.2174/0929866043406544
Price: $65

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