Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery

Author(s): E. ter Haar, W. P. Walters, S. Pazhanisamy, P. Taslimi, A. C. Pierce, G. W. Bemis, F. G. Salituro, S. L. Harbeson

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 3 , 2004

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Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and efficiencies to be gained. Specific examples from the SAPKfamily will be discussed.

Keywords: chemogenomics, kinases, structure-based drug design

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Article Details

Year: 2004
Page: [235 - 253]
Pages: 19
DOI: 10.2174/1389557043487367
Price: $65

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