Development of Radioligands for In Vivo Imaging of GABAA-Benzodiazepine Receptors

Author(s): Andrew Katsifis, Michael Kassiou

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 8 , 2004

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Changes in the biochemical integrity and function of the GABAA-benzodiazepine receptor (BZR) complex have been implicated in various neurological and psychiatric disorders. The development of specific radioligands for the GABAA-BZR have not only contributed to the elucidation of the receptors biochemical functions, but also provided a means by which these changes are correlated to disease states when studied with the functional imaging modalities of positron emission tomography (PET) and single photon emission computed tomography (SPECT).

Keywords: benzodiazepines, cns receptors, radioligands, pet, spect

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Article Details

Year: 2004
Page: [909 - 921]
Pages: 13
DOI: 10.2174/1389557043403332
Price: $65

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