Intervention of Hepatic Glucose Production. Small Molecule Regulators of Potential Targets for Type 2 Diabetes Therapy

Author(s): Tjeerd Barf

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 8 , 2004

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Excessive hepatic glucose production is thought to be a major contributor to the type 2 diabetic state. Drug discovery efforts have yielded small synthetic inhibitors for gluconeogenic and glycogenic regulators of this pathway. The most advanced targets are outlined in this mini-review and include: the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase type 1, fructose 1,6-bisphosphatase, the glucagon receptor, glycogen phosphorylase, glycogen synthase kinase-3, and glucose-6-phosphatase.

Keywords: glucocorticoid receptor, f16bpase, glycogen phosphorylase, glucagon receptor, gsk-3, g6pase

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Article Details

Year: 2004
Page: [897 - 908]
Pages: 12
DOI: 10.2174/1389557043403459
Price: $65

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