Bioactive Carbohydrates and Recently Discovered Analogues as Chemotherapeutics

Author(s): Tanja M. Wrodnigg, Friedrich K. (Fitz) Sprenger

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 4 , 2004

Become EABM
Become Reviewer
Call for Editor


Infectious diseases such as tuberculosis, malaria, the “simple flu” or HIV and HBV, are killing more than 50,000 people a day according to estimations by the World Health Organisation (WHO). Consequently, the development of biologically active agents in general, such as antibiotics and chemotherapeutics, is of great importance. Hand in hand with the understanding of the mechanisms of biological agents, structures carrying sugar moieties have become increasingly important during the last decades. This review will cover the most recent developments in the field of new antibiotics and synthetic agents containing carbohydrates which are active against tuberculosis and malaria. In addition, compounds having antiviral, antibacterial and anticancer properties will be examined. Compounds such as aminoglycosides, iminosugars, carbacycles, nucleosides, and other selected substance classes will be considered.

Keywords: carbohydrates, nucleosides, carbasugars, antibiotics, glycopeptide conjugates, chemotherapeutics

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2004
Page: [437 - 459]
Pages: 23
DOI: 10.2174/1389557043403918
Price: $65

Article Metrics

PDF: 2