Introduction: P2 Receptors

Author(s): Geoffrey Burnstock

Journal Name: Current Topics in Medicinal Chemistry

Volume 4 , Issue 8 , 2004

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The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor subtypes is described. This is followed by a summary of what is known of the distribution and roles of these receptor subtypes. Potential therapeutic targets of purinoceptors are considered, including those involved in cardiovascular, nervous, respiratory, urinogenital, gastrointestinal, musculo-skeletal and special sensory diseases, as well as inflammation, cancer and diabetes. Lastly, there are some speculations about future developments in the purinergic signalling field.

Keywords: p2 receptors, ligand gated ion channel, g protein-coupled p2y receptor, purinoceptors, purinergic signalling

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Article Details

Year: 2004
Page: [793 - 803]
Pages: 11
DOI: 10.2174/1568026043451014
Price: $65

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