Protein Z and Ischemic Stroke

Author(s): Y. Sun, F. Wen, H. Y. Yao

Journal Name: Vascular Disease Prevention (Discontinued)

Volume 2 , Issue 3 , 2005


protein Z (PZ) is a vitamin K-dependent plasma glycoprotein synthesized by the liver. Its structure is similar to other vitamin K-dependent coagulation factors. PZ plays an important role in mediating thrombosis and may be an independent risk factor for ischemic strokes. PZ mainly promotes the assembly of thrombus with phospholipids surfaces in a Ca2+-dependent fashion, thus enhancing coagulation. On the other hand, PZ binds with a specific PZ-dependent protease inhibitor (ZPI) to factor Xa and therefore indirectly acts as a natural anticoagulant. Therefore, PZ plays two paradoxical roles in vivo. It is connected with coagulation and anticoagulation and ischemic stroke. More research is needed to improve our understanding of PZs role in preventing and treating thrombosis.

Keywords: protein z, thrombosis, bleeding tendency, ischemic stroke, protein z-dependent protease inhibitor

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Article Details

Year: 2005
Published on: 01 March, 2012
Page: [245 - 250]
Pages: 6
DOI: 10.2174/1567270010502030245
Price: $65

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