Central retinal vein occlusion (CRVO) is a common visually disabling disease. Although CRVO is among the most common vascular disorders affecting the retina, second in prevalence only to diabetic retinopathy, there is a great deal of confusion regarding its management. The pathogenesis of CRVO is multifactorial with both local factors and systemic diseases being etiologically important. Various therapeutic regimens advocated include fibrinolytic or thrombolytic agents administered by various routes, anticoagulants, hemodilution, corticosteroids, acetazolamide, hyperbaric oxygen, complex medical therapy and other treatment modalities. The objective of this review is to evaluate the treatments commonly advocated, in the light of our current knowledge of CRVO.