Mannich-type Reaction of Methylene Active Compounds with a Chiral Sulfinimine of Trifluoropyruvate: New Highly Stereoselective Synthesis of (S)-α-Trifluoromethyl-Aspartic Acid

Author(s): Francesco Lazzaro, Arnaud Gissot, Marcello Crucianelli, Francesco De Angelis, Luca Bruche, Matteo Zanda

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 3 , 2005

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A strongly improved, highly stereoselective synthesis of (S)-α-trifluoromethyl aspartic acid via addition of lithium malonate to a chiral sulfinimine of trifluoropyruvate is presented.

Keywords: fluorine, sulfinimines, mannich-reaction, trifluoromethyl amino acids, stereoselective synthesis

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Article Details

Year: 2005
Page: [235 - 237]
Pages: 3
DOI: 10.2174/1570178053765348
Price: $65

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