New Approaches for the Treatment of Pain: The GDNF Family of Neurotrophic Growth Factors

Author(s): Dinah W. Y. Sah, Michael H. Ossipov, Anthony Rossomando, Laura Silvian, Frank Porreca

Journal Name: Current Topics in Medicinal Chemistry

Volume 5 , Issue 6 , 2005

Become EABM
Become Reviewer
Call for Editor


This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2005
Published on: 01 March, 2012
Page: [577 - 583]
Pages: 7
DOI: 10.2174/1568026054367593
Price: $65

Article Metrics

PDF: 9