Abstract
This review presents some therapeutic interventions actually considered in prostate cancer therapy to compensate constitutive activation of the PI3K/Akt signalling pathway induced, particularly, by mutations of PTEN gene. Special emphasis is placed on applicability of EGF-R tyrosine kinase, COX-2, PDK-1, mTOR and farnesyltransferase inhibitors.
Keywords: Prostate cancer, PI3K/Akt/mTOR pathway, growth inhibition
Mini-Reviews in Medicinal Chemistry
Title: Involvement of PI3K/Akt Pathway in Prostate Cancer - Potential Strategies for Developing Targeted Therapies
Volume: 5 Issue: 12
Author(s): Nicole Pommery and Jean-Pierre Henichart
Affiliation:
Keywords: Prostate cancer, PI3K/Akt/mTOR pathway, growth inhibition
Abstract: This review presents some therapeutic interventions actually considered in prostate cancer therapy to compensate constitutive activation of the PI3K/Akt signalling pathway induced, particularly, by mutations of PTEN gene. Special emphasis is placed on applicability of EGF-R tyrosine kinase, COX-2, PDK-1, mTOR and farnesyltransferase inhibitors.
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Pommery Nicole and Henichart Jean-Pierre, Involvement of PI3K/Akt Pathway in Prostate Cancer - Potential Strategies for Developing Targeted Therapies, Mini-Reviews in Medicinal Chemistry 2005; 5 (12) . https://dx.doi.org/10.2174/138955705774933356
DOI https://dx.doi.org/10.2174/138955705774933356 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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