Involvement of PI3K/Akt Pathway in Prostate Cancer - Potential Strategies for Developing Targeted Therapies

Author(s): Nicole Pommery, Jean-Pierre Henichart

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 12 , 2005

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This review presents some therapeutic interventions actually considered in prostate cancer therapy to compensate constitutive activation of the PI3K/Akt signalling pathway induced, particularly, by mutations of PTEN gene. Special emphasis is placed on applicability of EGF-R tyrosine kinase, COX-2, PDK-1, mTOR and farnesyltransferase inhibitors.

Keywords: Prostate cancer, PI3K/Akt/mTOR pathway, growth inhibition

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Article Details

Year: 2005
Page: [1125 - 1132]
Pages: 8
DOI: 10.2174/138955705774933356
Price: $65

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