Intravenous Immunoglobulin (IVIG) in Rheumatologic Diseases: A Review of its Mechanism of Action

Author(s): Martin N. Lee, Lavjay Butani

Journal Name: Current Rheumatology Reviews

Volume 1 , Issue 3 , 2005

Become EABM
Become Reviewer
Call for Editor


Intravenous Immunoglobulin (IVIG) has been used since the 1970s for the treatment of a variety of different rheumatologic and infectious diseases. While the therapeutic efficacy of IVIG has been definitively demonstrated in many different disorders, its mechanism(s) of action have remained poorly explained. This is complicated, in part by the difference in pathophysiology of the many diseases it has been used in the treatment of. Regardless of the types of diseases, understanding why transfusing pooled donor antibodies to unscreened patients fails to elicit a detrimental immunologic response, let alone benefit these patients, needs explanation. This review aims to explain how IVIG works by reviewing the medical literature and the relevant basic immunology involved.

Keywords: IVIG, immunology, rheumatic, mechanism, autoimmunity, immunoglobulin

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2005
Page: [289 - 293]
Pages: 5
DOI: 10.2174/157339705774612355
Price: $65

Article Metrics

PDF: 3