Title: Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Antiinflammatory 1,3,4-Thiadiazole Derivatives
VOLUME: 2 ISSUE: 1
Author(s):L. S. Varandas, C. A.M. Fraga, A. L.P. Miranda and E. J. Barreiro
Affiliation:Instituto de Química,Universidade Federal do Rio de Janeiro, Rio de Janeiro, R.J., Brazil.
Keywords:1,3,4-thidiazole derivatives, anti-inflammatory activity, analgesic and antiplatelet properties
Abstract: In this work we reported the design, synthesis and evaluation of the anti-inflammatory, analgesic, and antiplatelet properties of new 1,3,4-thiadiazole derivatives, structurally planed by exploiting the molecular hybridization approach between diuretic drug acetazolamide and a 1,3-benzodioxole COX-2 inhibitor, previously developed. The in vivo pharmacological evaluation of these new compounds lead us to identify the para-fluoro-substituted derivative 8b as a new prototype, more active that celecoxib at the same molar concentration.
