Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs

Author(s): M. S. Levi, M. O.F. Khan, R. F. Borne

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 1 , 2005

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The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 75-member library of N,6-disubstituted isoquinuclidines. A solution-phase method for their synthesis is described.

Keywords: addiction, ibogaine, isoquinuclidine, parallel synthesis, anti-addictive

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Article Details

Year: 2005
Page: [51 - 54]
Pages: 4
DOI: 10.2174/1570180053398217

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