Design and Synthesis of Combinatorial Scaffolds-Diazepinone and Homopiperazine

Chung-Ming      Sun

Volume 2, Issue 1, 2005

Page: [48 - 50] Pages: 3

DOI: 10.2174/1570180053398280

Price: $65

Abstract

A general method for the construction of diazepinone and homopiperazine scaffolds has been developed by utilizing Beckmann rearrangement as the key step in the design. Using this methodology, the synthesis of a diverse diazepinone library with three points of diversity has been achieved starting from readily available 4-piperidone.

Keywords: signal transduction, g-protein coupled receptors, piperazines, piperidines

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Letters in Drug Design & Discovery

Title: Design and Synthesis of Combinatorial Scaffolds-Diazepinone and Homopiperazine

Volume: 2 Issue: 1

Author(s): Chung-Ming Sun

Affiliation:

Keywords: signal transduction, g-protein coupled receptors, piperazines, piperidines

Abstract: A general method for the construction of diazepinone and homopiperazine scaffolds has been developed by utilizing Beckmann rearrangement as the key step in the design. Using this methodology, the synthesis of a diverse diazepinone library with three points of diversity has been achieved starting from readily available 4-piperidone.

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Sun Chung-Ming, Design and Synthesis of Combinatorial Scaffolds-Diazepinone and Homopiperazine, Letters in Drug Design & Discovery 2005; 2 (1) . https://dx.doi.org/10.2174/1570180053398280