Design and Synthesis of Combinatorial Scaffolds-Diazepinone and Homopiperazine

Author(s): Chung-Ming Sun

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 1 , 2005

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A general method for the construction of diazepinone and homopiperazine scaffolds has been developed by utilizing Beckmann rearrangement as the key step in the design. Using this methodology, the synthesis of a diverse diazepinone library with three points of diversity has been achieved starting from readily available 4-piperidone.

Keywords: signal transduction, g-protein coupled receptors, piperazines, piperidines

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Article Details

Year: 2005
Page: [48 - 50]
Pages: 3
DOI: 10.2174/1570180053398280

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