Title: Design and Synthesis of Combinatorial Scaffolds-Diazepinone and Homopiperazine
VOLUME: 2 ISSUE: 1
Author(s):Chung-Ming Sun
Affiliation:Department of chemistry, National Dong Hwa University, Shou-Feng, Hualien 974, Taiwan.
Keywords:signal transduction, g-protein coupled receptors, piperazines, piperidines
Abstract: A general method for the construction of diazepinone and homopiperazine scaffolds has been developed by utilizing Beckmann rearrangement as the key step in the design. Using this methodology, the synthesis of a diverse diazepinone library with three points of diversity has been achieved starting from readily available 4-piperidone.
