Inhibition of Transforming Growth Factor- βActivation is a Novel Effect of Chymase Inactivation

Author(s): S. Takai, M. Miyazaki

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 1 , 2005

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Chymase activates latent transforming-growth factorβ to transforming-growth factorβ in vitro. Recent papers demonstrate that transforming-growth factorβ levels and tissue fibrosis were significantly reduced by chymase inhibitors in the experimental models. Thus, transforming-growth factorβ-related diseases such as fibrosis may become a novel target of chymase inhibitors.

Keywords: adhesion, chymase, inhibitor, fibrosis, transforming growth factor

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Article Details

Year: 2005
Page: [19 - 22]
Pages: 4
DOI: 10.2174/1570180053398433

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