Title: Inhibition of Transforming Growth Factor- βActivation is a Novel Effect of Chymase Inactivation
VOLUME: 2 ISSUE: 1
Author(s):S. Takai and M. Miyazaki
Affiliation:Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.
Keywords:adhesion, chymase, inhibitor, fibrosis, transforming growth factor
Abstract: Chymase activates latent transforming-growth factorβ to transforming-growth factorβ in vitro. Recent papers demonstrate that transforming-growth factorβ levels and tissue fibrosis were significantly reduced by chymase inhibitors in the experimental models. Thus, transforming-growth factorβ-related diseases such as fibrosis may become a novel target of chymase inhibitors.
