Bakers Yeast Reduction of PEG-Linked Acetoacetate

Author(s): G. M. Bonora, S. Drioli, C. Forzato, P. Nitti, G. Pitacco

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 1 , 2005

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Bioreduction of PEG-acetoacetate 1 is achieved using dry bakers yeast in toluene with a small amount of added water. After detachment from the polymer under basic conditions, the corresponding (S)-(+)- 3-hydroxybutanoic acid 3 was esterified with Me3SiCl and ethanol and ethyl (S)-(+)-3-hydroxybutanoate 4 was isolated with 97% e.e. and 70% overall yield.

Keywords: baker yeast, bioreduction, organic solvent, peg

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Article Details

Year: 2005
Page: [89 - 91]
Pages: 3
DOI: 10.2174/1570178053400135

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