Why has Cerium (III) Triflate been Forgotten Among the Catalysts for the Friedel-Crafts Acylation?

Author(s): Giuseppe Bartoli, Antonio De Nino, Renato Dalpozzo, Loredana Maiuolo, Monica Nardi, Antonio Procopio, Antonio Tagarelli

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 1 , 2005

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Cerium is the less rare “rare earth”; its salts are commercially available and inexpensive. However, screening of lanthanide triflates as Lewis acid catalysts in the Friedel-Crafts acylation of aromatics skipped cerium triflate. Now, catalytic Friedel-Crafts acylations of activated benzenes are performed by using cerium (III) triflate as catalyst. For less activated arenes, addition of lithium perchlorate as co-catalyst is required. In all cases aromatic ketones are obtained in very good yields.

Keywords: electrophilic substitution, lewis acid catalysis, anhydrides, arenes, lanthanide triflates, lithium perchlorate

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Article Details

Year: 2005
Page: [51 - 53]
Pages: 3
DOI: 10.2174/1570178053400153

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